Endocrine Abstracts

Cell and tissue damage, particularly to pancreatic β-cells, is an essential characteristic of diabetes mellitus, triggered by autoimmune destruction of β-cells in type-1 (T1D) and by obesity associated factors or insulin resistance in type 2. Thus, stimulating β-cell regeneration has long been a most important goal of diabetes research. Recently, we have shown that pancreatic injury consisting of acinar cell inflammation and β-cell destruction led to islet ...